Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1
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چکیده
منابع مشابه
Apoptotic protease-activating factor 1 (Apaf-1) as a liable gene for spontaneous mutations in vitro
The apoptotic protease-activating factor 1 (Apaf-1) receives the death signal in the intrinsic ormitochondrial pathway of apoptosis. Upon the releasing of cytochrome c from theintermembrane space of mitochondria and binding to Apaf-1 molecules, a heptamericapoptosome complex is formed and triggers the downstream cascade of caspases. Here, for thefirst time we present spontaneous mutations and r...
متن کاملPYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.
Recently, a large subfamily of nucleotide-binding and oligomerization domain-containing proteins that have an N-terminal pyrin-like domain and C-terminal leucine-rich repeats has been described. In this study, we identified PYNOD, a novel member of this family that lacks the leucine-rich repeats. We found that human PYNOD mRNA is expressed in various tissues and at high levels in heart, skeleta...
متن کاملAPAF 1 ( Apoptotic protease activating factor 1 )
Five isoforms of APAF1 cDNA have been identified in Homo sapiens: The original APAF1 (also called Apaf-1S) is 3585 bp long (it contains 12 WD40 repeats); The APAF1-1M isoform (3618 bp) contains an insertion of 33 nt after position 295 of the first published sequence (11 aa insertion GKDSVSGITSY between aa 98 and 99; it also contains 12 WD40 repeats); The APAF1XS isoform (3516 bp) contains the s...
متن کاملApoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)/target of methylation-induced silencing/PYCARD represents one of only two proteins encoded in the human genome that contains a caspase recruitment domain (CARD) together with a pyrin, AIM, ASC, and death domain-like (PAAD)/PYRIN/DAPIN domain. CARDs regulate caspase family proteases. We show here that ASC binds...
متن کاملapoptotic protease-activating factor 1 (apaf-1) as a liable gene for spontaneous mutations in vitro
the apoptotic protease-activating factor 1 (apaf-1) receives the death signal in the intrinsic ormitochondrial pathway of apoptosis. upon the releasing of cytochrome c from theintermembrane space of mitochondria and binding to apaf-1 molecules, a heptamericapoptosome complex is formed and triggers the downstream cascade of caspases. here, for thefirst time we present spontaneous mutations and r...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2006
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxl104